Production agriculture and the practical use of pesticides are among the many threats to endangered species. Pesticides are regulated by the U.S. Environmental Protection Agency (EPA) and instances of potential harm must be addressed by law, whether through court action or regulation. Possible limitations on available chemicals are of serious concern to farmers, as are numerous other challenges: pesticide resistance, fertilizer prices, global markets, extreme weather, water, regulatory challenges, and pesticide stewardship. The EPA has established a vulnerable species pilot project, and its workplan is intended to protect endangered and threatened species from pesticides.