Herbicide-resistant Palmer amaranth (Amaranthus palmeri) is a serious concern in cotton, with seed production and seedbank replenishment by uncontrolled weed escapes directly impacting production and profitability. This study is centered on seedbank management as a key aspect of herbicide-resistant weed management by exploring integrated management tactics implemented throughout the growing season. This multi-state study, initiated in 2020, has been ongoing in Raleigh, North Carolina; Marianna, Arkansas; College Station, Texas; and Lubbock, Texas. Results so far demonstrate the value of integrating residual herbicides and targeting weed escapes in the late season in minimizing seedbank inputs. Findings of this ongoing experiment are expected to help develop regionally suitable integrated weed management programs in cotton for reducing Palmer amaranth infestations in the long term.