From 1961 to 2010, target spot was barely a blip on cotton farmer’s radars. But since 2010, it has had a growing presence in the Southeast U.S. and has been advancing toward other cotton production areas in the United States. But with some key management practices, growers who are affected with this disease have the opportunity to both save yield make money with the use of fungicides. The presentation is broken up into two parts. Part one discusses the disease itself, its origins, symptoms, and development. Environmental factors that affect the disease, its current distribution, and variety selection are also discussed. In the second part, we discuss the use of fungicides to manage this resurging disease.