Herbicide-resistant Italian ryegrass is a troublesome weed that plagues cotton production across the Belt. In 2021, paraquat-resistant Italian ryegrass was confirmed in North Carolina. Even more alarming, this biotype is also resistant to glyphosate, ACCase-inhibitors, and ALS-inhibitors. This presentation discusses the history of herbicide-resistant Italian ryegrass, the recent confirmation of paraquat-resistant Italian ryegrass in North Carolina, and potential tactics for management of multiple-resistant biotypes.