Have you ever listened to a scientific presentation and heard the phrase “but the differences were not significant”? Or have you ever wondered why researchers put letters next to numbers in tables or on graphs? This presentation will answer these questions. Additionally, this presentation will help viewers make sense of how information is used in relation to making claims about performance of products used in crop production. Specifically, the presentation will present examples of how data are collected from small-plot and large-scale research trials, show how those data should be presented, and answer the question "Is it really significant to me?"