This presentation will help consultants, growers, and other practitioners in the North-Central, and Southern U.S. evaluate how tillage is being used in their production system to combat herbicide-resistant weeds, an increasingly critical and widespread challenge. Specifically, the role of tillage in managing herbicide-resistant weeds will depend on the type and timing of the tillage performed; which aspect of weed management, the seeds or plants of weeds, is being targeted with the tillage operation; and how tillage may influence the implementation of other management practices such as herbicide use. By the end of this presentation, the practitioner should have a greater appreciation for the factors that influence the weed management benefits provided by tillage as well as some of the pitfalls of tillage for both short- and long-term management of herbicide-resistant weeds.