​​​A Role for Oomycete Biology in the Development of Disease Resistant Soybean

May 2015 | 9 min., 15 sec.
by Kevin Fedkenheuer, Michael Fedkenheuer, and John McDowell
Virginia Tech

Summary

In order to improve plant resistance against disease, we must understand the mechanisms which drive resistance and susceptibility. Phytophthora sojae, an oomycete pathogen, is the causal agent of soybean root and stem rot and was responsible for over 2% crop loss in 2006. In this presentation, we discuss how P. sojae infiltrates host cells and how host resistance (R) genes can prevent pathogen growth. Despite many management techniques, the Resistance to Phytophthora sojae (RPS) genes are most effective. Using this information, we hope to engineer durable resistance against P. sojae. We highlighted three USDA-NIFA funded projects which are using oomycete biology to improve resistance against soybean root and stem rot. The objective of this presentation is to highlight a role for oomycete biology in the development of disease resistant soybean.​

About the Presenter

Kevin Fedkenheuer Kevin Fedkenheuer is a fifth year PhD student. He earned his BS with a major in Biotechnology and a minor in Chemistry from James Madison University in 2010. At JMU, he worked on the role of beta-amylase proteins in starch degradation with Dr. Jon Monroe. In 2011, he joined the Department of Plant Pathology, Physiology, and Weed Science at Virginia Tech working with Dr. John McDowell. His expertise is in plant-pathogen transcriptomics and in soybean genetic resistance against Phytophthora sojae.




Michael Fedkenheuer Michael Fedkenheuer is a third-year PhD student. He earned his BS with a major in biotechnology and a minor in chemistr​y from James Madison University (JMU) in 2010; there, he worked on the development of a Dengue virus vaccine with Amanda Biesecker. In 2011, he joined the Department of Biochemistry at Virginia Tech with Pablo Sobrado; he studied the structural biology of flavin-containing monooxygenases. In 2012, he graduated with a master’s degree in biochemistry and joined the Department of Plant Pathology, Physiology, and Weed Science at Virginia Tech, working with John McDowell. Michael’s expertise is in structural biology, x-ray crystallography, and wild soybean resistance against Phytophthora sojae.

John McDowell John McDowell is a professor in the Department of Plant Pathology, Physiology, and Weed Science at Virginia Tech. He received his PhD in 1995 from the University of Georgia under the guidance of Rich Meagher; his dissertation was on the structure, expression, and evolution of actin genes in Arabidopsis. He then entered the molecular plant–microbe interactions field through postdoctoral research in Jeff Dangl’s lab at the University of North Carolina, Chapel Hill; there, he studied the structure, evolution, and signaling of disease resistance (R) genes in Arabidopsis, with emphasis on genes against the oomycete pathogen Hyaloperonospora arabidopsidis (downy mildew). In 2000, Dr. McDowell started his own group at Virginia Tech to continue investigating plant–oomycete interactions. His group explores the mechanisms through which plant cells succumb to manipulation by oomycete pathogens.

Contact Information:
Email: fedkenke@vt.edu, fedkenmg@vt.edu, johnmcd@vt.edu

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​Grant Funding

​This webcast was supported by funds provided through USDA-NIFA.


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