Giant Ragweed is one of the most problematic and competitive weeds in U.S. soybean and corn production. Its problematic nature is further compounded by a growing trend of evolution of biotypes that are resistant to ALS herbicides, glyphosate, and possibly others in the near future. This presentation will cover some of the basic aspects of the biology of giant ragweed and control measures, specifically for soybean production. It will also cover other unique aspects of giant ragweed such as its ability to serve as an alternative host for stem boring insects and how these insects can influence control with post emergence herbicides.